In March, selected tests will be retired from the GeneDx catalog. These changes to our test menu are an important step toward achieving our mission: delivering personalized and actionable health insights to inform diagnosis for all patients who can benefit. We remain steadfastly focused on this goal and believe the best way to achieve it is through exome and genome sequencing.
Below you will find a detailed list of the tests impacted and key dates for last order and sample acceptance.
Tests being retired and suggested GeneDx replacement options when available
| Test code | Test name | Replacement test |
|---|---|---|
| J660 | NF1 Sequencing & Del/Dup | NF1 Panel (test code: 962) |
| TG78 | Congenital Hypotonia Evaluation | XomeDx® – Trio (test code: 561a) XomeDx® – Duo (test code: 561e) XomeDx® – Proband (test code: 561b) GenomeSeqDx – Trio (test code: J774a) GenomeSeqDx – Duo (test code: J774e) GenomeSeqDx – Proband (test code: J774b) or all 3 of the standalone tests: Dosage Analysis of SNM1 & SMN2 (test code: T789); DMPK Repeat Analysis (test code: 818); and Angelman Syndrome/Prader-Willi Syndrome Methylation Analysis (test code: TJ27) |
| 953 | Epilepsy Del/Dup Panel | XomeDx® – Trio (test code: 561a) XomeDx® – Duo (test code: 561e) XomeDx® – Proband (test code: 561b) GenomeSeqDx – Trio (test code: J774a) GenomeSeqDx – Duo (test code: J774e) GenomeSeqDx – Proband (test code: J774b) |
| TA41 | Ectrodactyly/Split Hand-Split Foot Malformation Panel | Limb Abnormalities and Reduction Defects Panel (test code: TA42) |
| TL27 | NICUXpress Panel | XomeDxXpress® – Trio (test code: 896a) XomeDxXpress® – Duo (test code: 896e) XomeDxXpress® – Proband (test code: 896b) GenomeXpress® – Trio (test code: TH78a) GenomeXpress® – Duo (test code: TH78e) GenomeXpress® – Proband (test code: TH78b) |
| TB51 | Comprehensive Holoprosencephaly Panel | XomeDx® – Trio (test code: 561a) XomeDx® – Duo (test code: 561e) XomeDx® – Proband (test code: 561b) GenomeSeqDx – Trio (test code: J774a) GenomeSeqDx – Duo (test code: J774e) GenomeSeqDx – Proband (test code: J774b) |
| J899 | Hereditary Pancreatitis Panel | No replacement available |
| TL54 | Prenatal L1CAM Sequencing and Del/Dup | No replacement available |
| 188 | HPS1 & HPS3 Mutation Analysis (Puerto Rican) | No replacement available |
To view complete list of available test options, visit the GeneDx test menu
Key dates
| March 17, 2025 | March 31, 2025 |
|---|---|
| Last day to place an order via the portal | 1. Last day to place an order via paper test requisition form (TRF) (accompanied by the sample) 2. Last day that samples will be accepted (portal or TRF orders) |
If you place an order for these tests through an EMR, please contact your EMR provider to update your ordering system.
Questions? We’re happy to help. Please contact our client services team at 888-729-1206 option 3 or Support@GeneDx.com.
At GeneDx, we believe the most efficient way to find a diagnosis is through exome and genome sequencing. With their more comprehensive scope, exome and genome sequencing are more likely to deliver a genetic diagnosis than multigene panels.1-4 What’s more, they report fewer variants of uncertain significance than panels4 and the data can be reanalyzed. For many indications, ordering an exome or genome test leads to more answers for more patients—unlocking new treatments and ultimately reducing healthcare expenses.5
References: 1. Manickam K, McClain MR, Demmer LA, et al. Genet Med. 2021 Nov;23(11):2029-2037. doi: 10.1038/s41436-021-01242-6. 2. Dillon OJ, Lunke S, Stark Z, et al. Eur J Hum Genet. 2018 May;26(5):644-651. doi: 10.1038/s41431-018-0099-1. 3. Sheidley BR, Malinowski J, Bergner AL, et al. Epilepsia. 2022 Feb;63(2):375-387. doi: 10.1111/epi.17141. 4. Rehm H, Alaimo JT, Aradhya S, et al. Genet Med. 2023 Jul 30;100947. doi: 10.1016/j.gim.2023.100947. 5. Tan TY, Dillon OJ, Stark Z, et al. JAMA Pediatr. 2017;171(9):855. doi:10.1001/jamapediatrics.2017.1755
